| N° | Joueur | Club | Buts | Pen. | MJ | Min | B/Min | |
| 1 | Lionel Messi | FC Barcelone | 37 | 6 | 34 | 2832 | / 77 Min | |
| 2 | Luis Suárez | FC Barcelone | 29 | 0 | 35 | 2865 | / 99 Min | |
| 3 | Cristiano Ronaldo | Real Madrid | 25 | 6 | 29 | 2544 | / 102 Min | |
| 4 | Iago Aspas | Celta Vigo | 19 | 6 | 32 | 2319 | / 122 Min | |
| 5 | Antoine Griezmann | Atlético Madrid | 16 | 0 | 36 | 3067 | / 192 Min | |
| 6 | Aduriz | Athletic Bilbao | 16 | 5 | 32 | 2463 | / 154 Min | |
| 7 | Álvaro Morata | Real Madrid | 15 | 0 | 26 | 1330 | / 89 Min | |
| 8 | Sandro Ramírez | Malaga | 14 | 0 | 30 | 2316 | / 165 Min | |
| 9 | Gerard | Espanyol | 13 | 0 | 37 | 3280 | / 252 Min | |
| 10 | Neymar | FC Barcelone | 13 | 1 | 30 | 2652 | / 204 Min | |
| 11 | Rubén Castro | Bétis Séville | 13 | 2 | 35 | 2783 | / 214 Min | |
| 12 | Florin Andone | Deportivo La Corogne | 12 | 0 | 37 | 2900 | / 242 Min | |
| 13 | Kevin Gameiro | Atlético Madrid | 12 | 1 | 31 | 1716 | / 143 Min | |
| 14 | Willian José | Real Sociedad | 12 | 3 | 28 | 2078 | / 173 Min | |
| 15 | Cédric Bakambu | Villarreal | 11 | 0 | 26 | 1570 | / 143 Min | |
| 16 | Juanmi | Real Sociedad | 11 | 0 | 35 | 1834 | / 167 Min | |
| 17 | Karim Benzema | Real Madrid | 11 | 0 | 29 | 1914 | / 174 Min | |
| 18 | Sergi | Eibar | 11 | 0 | 38 | 2828 | / 257 Min | |
| 19 | Wissam Ben Yedder | FC Séville | 11 | 1 | 31 | 1666 | / 151 Min | |
| 20 | Isco | Real Madrid | 10 | 0 | 30 | 1637 | / 164 Min |